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KMID : 1123920140280040403
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 4 p.403 ~ p.410
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Anti-Depressive Effects of OnDam-Tang with Addition of Linderae Radix (ODT-L) after Chronic Immobilization Stress in C57BL/6 Mice
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Lee Eun-Hee
Jung In-Chul
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Abstract
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The purpose of this study was to examine the anti-depressive effects of OnDam-Tang with addition of Linderae Radix (ODT-L) on the animal model of depression induced by chronic immobilization stress. Depression model was made by chronic immobilization stress for 2 hours for 21 days. And we performed forced swimming test, analysis of the neurotransmitter and immunohistochemical staining, measured expression levels of serotonin in the brain. ODT-L has decreased immobilization time in forced swimming test. ODT-L has increased amount of melatonin in the brain. ODT-L has increased expression levels of serotonin in the brain. ODT-L prevented damage in the hippocampal region. ODT-L has reduced the expression level of CRF receptors in in hippocampus region. These results suggest that ODT-L may have anti-depressive effects on depression.
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KEYWORD
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OnDam-Tang with addition of Linderae Radix (ODT-L), Immobilization stress, Anti-depressive effect, Depression, Serotonin
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